Author

T. Durcan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

I. Shlaifer· 2 shared J.-F. Trempe· 2 shared R. Thomas· 2 shared Z. You· 2 shared A. Alkhoury· 1 shared A. Bayne· 1 shared A. Chapleau· 1 shared A. Edwards· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

I. Shlaifer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

S. A. Rial, Z. You, A. Vivoli, D. Sean, A. Alkhoury, G. Lavoie, M. Civelek, A. Martinez-sanchez, P. P. Roux, T. Durcan, G. Lim

This study shows 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility in adipose precursor cells, impacting gene expression and fat mass.

bioRxiv · Mar 18, 2024 · PreprintPhysiology

The Use of a SOX10 Reporter Towards Ameliorating Oligodendrocyte Lineage Differentiation from Human Induced Pluripotent Stem Cells

V. E. C. Piscopo, A. Chapleau, G. J. Blaszczyk, J. Sirois, Z. You, V. Soubannier, G. Bernard, J. P. Antel, T. Durcan

The paper develops a SOX10 reporter system to improve the differentiation of oligodendrocytes from iPSCs, enhancing reproducibility and maturity.

bioRxiv · Dec 1, 2023Cell Biology

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

B. Vanderperre, A. Muraleedharan, M.-F. Dorion, F. Larroquette, E. Del Cid Pellitero, N. Rajakulendran, C. X.- Q. Chen, R. Lariviere, C. Michaud-Tardif, R. Chidiac, D. Lipuma, G. Macleod, R. Thomas, Z. Wang, W. E. Reintsch, , E. A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

TOM20 Gates PINK1 Activity And Mediates Its Tethering Of The TOM And TIM23 Translocases Upon Mitochondrial Stress

M. Eldeeb, A. Bayne, A. Fallahi, T. Goiran, E. McDougall, A. Soumbasis, C. Zorca, J.-J. Tabah, R. Thomas, N. Karpilovsky, M. Mathur, T. Durcan, J.-F. Trempe, E. Fon

This study shows PINK1 forms a supercomplex with TOM and TIM23 during mitochondrial stress and is required for tethering TOM to TIM23, which is essential for mitophagy.

bioRxiv · Aug 7, 2023Biochemistry

The identification of potent and selective antibodies for Serine/threonine-protein kinase TBK1, for use in immunoblot, immunofluorescence and immunoprecipitation

W. Alshafie, M. Fotouhi, I. Shlaifer, A. Edwards, T. Durcan, P. S. McPherson, C. Laflamme

The paper evaluates 11 commercial antibodies for TBK1 detection in immunoblot, immunofluorescence, and immunoprecipitation using a knock-out cell line to identify potent and selective antibodies.

bioRxiv · Jun 3, 2022 · PreprintBiochemistry