TOM20 Gates PINK1 Activity And Mediates Its Tethering Of The TOM And TIM23 Translocases Upon Mitochondrial Stress
M. Eldeeb, A. Bayne, A. Fallahi, T. Goiran, E. McDougall, A. Soumbasis, C. Zorca, J.-J. Tabah, R. Thomas, N. Karpilovsky, M. Mathur, T. Durcan, J.-F. Trempe, E. Fon
This study shows PINK1 forms a supercomplex with TOM and TIM23 during mitochondrial stress and is required for tethering TOM to TIM23, which is essential for mitophagy.
bioRxiv · Aug 7, 2023Biochemistry