DJ-1 (Park7) affects the gut microbiome, metabolites, and development of Innate Lymphoid Cells (ILCs)
Y. Singh, C. Trautwein, A. Dhariwal, M. S. Salker, M. Alauddin, L. Zizmare, L. Pelzl, M. Feger, J. Matthes, N. Casadei, M. Föller, V. Pachauri, D. S. Park, T. W. Mak, J. S. Frick, , O. Riess
This study shows that DJ-1 deficiency in mice alters gut microbiome composition, increases inflammatory markers, and reduces innate lymphoid cells, potentially contributing to Parkinson's disease pathogenesis.
bioRxiv · Sep 19, 2019Immunology