Y. Singh

Bimodular Architecture of Bacterial Effector SAP05 Drives Ubiquitin-Independent Targeted Protein Degradation

This paper reports the crystal structures of SAP05 complexes and reveals their bimodular architecture enabling ubiquitin-independent targeted protein degradation in eukaryotic cells.

Maintained imbalance of triglycerides, apolipoproteins, energy metabolites and cytokines in long-term COVID-19 syndrome (LTCS) patients

This study identifies persistent metabolic, proteomic, and immunologic imbalances in long-term COVID-19 syndrome (LTCS) patients compared to healthy controls and acute COVID-19 patients.

Comparative multi-OMICS single-cell atlas of five COVID-19 (rAdVV and mRNA) vaccines describe unique and distinct mechanisms of action

This study compares the mechanisms of action of five COVID-19 vaccines using multi-omics single-cell data, revealing distinct immune responses and cell-type-specific effects.

Immune dynamics at single cell protein level after delta/omicron infection in COVID-19 vaccinated convalescent individuals

This study examines immune dynamics at the protein level in vaccinated individuals infected with delta or omicron variants, finding reduced NK cells and increased T and B cells, and that booster doses reduce infection severity.

Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cells in recovered COVID-19 pregnant women

This study uses single-cell RNA sequencing to show that SARS-CoV-2 infection reduces cytotoxic function in natural killer and CD8+ T cells in recovered pregnant women.

Transcriptome analysis reveals robust transcriptional reprogramming during early stages of Cicer-Ascochyta interaction

This study compares transcriptional responses of AB-resistant and susceptible chickpea genotypes to A. rabiei infection, identifying key pathways and hub genes involved in resistance.

GWAS and functional studies implicate a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

This study identifies DNA repair gene mutations linked to drug resistance in Mycobacterium tuberculosis through GWAS and functional experiments.

Bacillus anthracis chain length, a virulence determinant, is regulated by a transmembrane Ser/Thr protein kinase PrkC

This study identifies PrkC, a transmembrane Ser/Thr kinase in B. anthracis, as a regulator of bacterial chain length, which impacts virulence and pathophysiological outcomes.

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

This study examines how SARS-CoV-2 infection affects CD8+ T cell cytotoxicity and immune cell metabolism in COVID-19 patients.

Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hotspots, Functional Crosstalk and Regulatory Interactions in SARS-CoV-2

The paper analyzes SARS-CoV-2 genomic variations and host-pathogen interactions to identify mutational patterns, co-mutations, and functional implications in USA strains.

Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution

This study analyzes SARS-CoV-2 genomes from global isolates to reveal mosaic phylogeographical patterns and identify unique mutations associated with immune evasion mechanisms.

DJ-1 (Park7) affects the gut microbiome, metabolites, and development of Innate Lymphoid Cells (ILCs)

This study shows that DJ-1 deficiency in mice alters gut microbiome composition, increases inflammatory markers, and reduces innate lymphoid cells, potentially contributing to Parkinson's disease pathogenesis.

Gut bacterial metabolite Urolithin A (UA) mitigates Ca2+ 1 entry inT cells by regulating miR-10a-5p

This study shows that gut metabolite UA reduces T cell proliferation by increasing miR-10a-5p and decreasing Orai1/STIM1/STIM2 expression and SOCE in murine CD4+ T cells.