C. Trautwein

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPAR alpha and PCK1 action in hepatocytes

This study shows intermittent fasting prevents NASH and HCC by PPAR alpha and PCK1 working together in liver cells.

Maintained imbalance of triglycerides, apolipoproteins, energy metabolites and cytokines in long-term COVID-19 syndrome (LTCS) patients

This study identifies persistent metabolic, proteomic, and immunologic imbalances in long-term COVID-19 syndrome (LTCS) patients compared to healthy controls and acute COVID-19 patients.

Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis

Retinal metabolism: Evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle

This paper investigates retinal energy metabolism, revealing that photoreceptors use distinct metabolic pathways, including the mini-Krebs, Cahill, and Cori cycles, to uncouple glycolysis from oxidative phosphorylation.

DeepMed: A unified, modular pipeline for end-to-end deep learning in computational pathology

DeepMed provides a modular, scalable AI pipeline for predicting molecular and histopathological features from histopathology images, with public benchmark data.

Classical Mathematical Models for Prediction of Response to Chemotherapy and Immunotherapy

This study evaluates classical mathematical models for predicting chemotherapy and immunotherapy responses using real-world patient tumor volume data, finding the Gompertz model provides the best balance between fit and complexity.

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

This study examines how SARS-CoV-2 infection affects CD8+ T cell cytotoxicity and immune cell metabolism in COVID-19 patients.

DJ-1 (Park7) affects the gut microbiome, metabolites, and development of Innate Lymphoid Cells (ILCs)

This study shows that DJ-1 deficiency in mice alters gut microbiome composition, increases inflammatory markers, and reduces innate lymphoid cells, potentially contributing to Parkinson's disease pathogenesis.

Deep learning detects virus presence in cancer histology

This paper uses deep learning to detect the presence of HPV and EBV in cancer histology images, achieving high accuracy in predicting virus-associated tumors.