Author

M. Francis

Primary ORCID profile (0000-0002-1228-1570 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

M. FrancisiD1 paper · University of Colorado Anschutz

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

D. Falzarano· 2 shared J. Kindrachuk· 2 shared V. Gerdts· 2 shared A. A. A. Kelvin· 1 shared A. A. Kelvin· 1 shared A. Etzioni· 1 shared A. Ge· 1 shared A. Kroeker· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

D. Falzarano

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

M. Francis, P. Sheshadri, J. Prasanna, A. Kumar

This study identifies USP1 as a deubiquitinase promoting β-cell dedifferentiation in diabetes and shows its inhibition can rescue hyperglycaemia.

bioRxiv · Oct 14, 2022Cell Biology

SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

M. Francis, U. Goncin, A. Kroeker, C. Swan, R. Ralph, Y. Lu, A. Etzioni, D. Falzarano, V. Gerdts, S. Machtaler, J. Kindrachuk, A. A. Kelvin

This study shows SARS-CoV-2 infection in Syrian hamsters causes inflammation and type I interferon suppression in multiple organs, including the heart and kidney, similar to human COVID-19 symptoms.

bioRxiv · Apr 7, 2021Microbiology

Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets

M. Francis, B. Richardson, M. McNeil, M. Rioux, M. Foley, A. Ge, R. Pechous, J. Kindrachuk, C. Cameron, C. Richardson, J. Lew, M. Cameron, V. Gerdts, D. Falzarano, A. A. A. Kelvin

This study shows that male sex and age in ferrets affect viral burden, shedding, and interferon responses during SARS-CoV-2 infection, with older males showing delayed antiviral responses.

bioRxiv · Jan 12, 2021Microbiology

The peptide sensor motif stabilizes the outward-facing conformation of TmrAB

C. R. Millan, M. Francis, V. F. Thompson, T. M. Thaker, T. M. Tomasiak

This study investigates how the peptide sensor motif in TmrAB coordinates conformational changes during ATP-dependent transport, showing it stabilizes the outward-facing state.

bioRxiv · Jan 12, 2020 · PreprintBiochemistry