T. Voet

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cells

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

Integration of Multiple Spatial-Omics Modalities Reveals Unique Insights into Molecular Heterogeneity of Prostate Cancer

This paper integrates multiple spatial-omics modalities in prostate cancer samples to reveal molecular heterogeneity and correlations between lipids and gene expression.

A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma

This study identifies a TCF4/BRD4-dependent regulatory network that drives cross-resistance to ICB and targeted therapy in melanoma by analyzing scRNA-seq data from a longitudinal cohort.

Neuro-immune Crosstalk in the Enteric Nervous System from Early Postnatal Development to Adulthood

This study shows that intestinal macrophages refine the enteric nervous system early in life by pruning synapses and phagocytosing neurons, and maintain neuron survival post-weaning through a TGFβ-driven microglia-like phenotype.

A neural crest stem cell-like state drives nongenetic resistance to targeted therapy in melanoma

This study identifies a neural crest stem cell-like state in melanoma minimal residual disease that drives nongenetic resistance to MAPK-targeted therapy and shows that targeting FAK/SRC signaling can delay relapse.

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.