A. Mathur

Reprogramming human B cells with custom heavy chain antibodies

This paper describes a genome editing strategy to reprogram human B cells to express custom heavy chain antibodies that respond to immunization.

Comparison of shear stress patterns by the established and advanced reconstruction method incorporating side branches to predict plaque progression

This study compares wall shear stress (WSS) metrics from complete vessel reconstruction (CVR) and single vessel reconstruction (SVR) methods to assess their ability to predict atherosclerotic disease progression.

Deciphering drug response and phenotypic heterogeneity of cancer cells using gene ensembles of regulatory units defined by chromatin domains

The paper analyzes the relationship between TAD activity and drug response in cancer cells and patients, finding stronger correlations with TADs than individual genes.

GBP1 promotes killing of multidrug-resistant Acinetobacter baumannii and promotes host protection via interferon signalling and inflammasome activation.

This study shows GBP1 and interferon signaling enhance host defense against multidrug-resistant A. baumannii by promoting inflammasome activation and killing resistant bacteria.

Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains

This study compares the activation of the NLRP3 inflammasome and programmed cell death by different Acinetobacter baumannii strains in macrophages and mice, revealing strain-specific differences in virulence and immune response.

Measuring effects of trainee professional development on research productivity: A cross-institutional meta-analysis

This study analyzes the impact of professional development programs on doctoral students' research productivity and time to degree across ten institutions, finding no negative effects and some positive correlations.

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.

Cytoskeleton mechanics determine resting size and activation dynamics of platelets.

This study shows that platelet size is linked to microtubule content and that actin-driven coiling of the marginal band occurs during activation, with larger platelets showing greater coiling propensity.

Balance of microtubule stiffness and cortical tension determines the size of blood cells with marginal band across species

The paper models how the size of blood cells with marginal bands is determined by the balance between microtubule stiffness and cortical tension, verified across 25 species.