Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses
S. E. Jossi, M. Arcuri, A. Alshayea, R. R. Persaud, E. Marcial-Juarez, E. Palmieri, R. Di Benedetto, M. Perez-Toledo, J. Pillaye, W. M. Channell, A. E. Schager, R. E. Lamerton, C. N. Cook, M. Goodall, T. Hanaeda, , A. F. Cunningham
This study compares the efficacy of Vi polysaccharide and conjugated Vi vaccines in protecting against Salmonella Typhi, finding that conjugated vaccines sustain immune responses better over time.
bioRxiv · Jan 3, 2023 · PreprintImmunology