Targeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma
N. Thongon, F. Ma, P. Lockyer, N. Baran, J. Liu, C. Jackson, A. Rose, B. Wildeman, M. Marchesini, V. Marchica, P. Storti, N. Giuliani, I. Ganan-Gomez, V. Adema, Y. Qing, , S. Colla
This study identifies DNA2 as a key factor in mitochondrial metabolism that enables multiple myeloma cells to survive DNA damage, showing that targeting DNA2 overcomes metabolic reprogramming and enhances therapy effectiveness.
bioRxiv · Feb 22, 2023Cancer Biology