Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus
N. Wang, S. Han, R. Liu, L. Meng, H. He, Y. Zhang, C. Wang, Y. Lv, J. Wang, X. Li, Y. Ding, J. Fu, Y. Hou, W. Lu, W. Ma, , L. He
This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.
bioRxiv · Jun 22, 2020Biochemistry