The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection
J. F. Quintana Alcala, M. C. Sinton, P. Chandrasegaran, L. K. Dubey, J. Ogunsola, M. A. Samman, M. Haley, G. McConnell, N. R. Kuispond Swar, D. M. Ngoyi, D. Bending, L. de Lecea, A. MacLeod, N. A. Mabbott
This study shows that chronic Trypanosoma brucei infection in mice causes meningeal lymphoid aggregates with autoreactive B cells and autoantibodies against brain antigens.
bioRxiv · Apr 30, 2023 · PreprintImmunology