D. Bending

LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor

This study identifies a transcriptomic signature predicting CD8+ T cell clone expansion rates and shows LAG-3 blockade reactivates this signature to re-expand contracted clones in tumors.

Vancomycin impairs macrophage fungal killing by disrupting mitochondrial morphology and function

This study shows vancomycin impairs macrophage fungal killing by disrupting mitochondrial function and morphology, independent of microbiome effects.

Interferonγ and IL-27 positively regulate type 1 regulatory T-cell development during adaptive tolerance

This study shows that IFNγ and IL-27 enhance Tr1 cell development during strong TCR signaling in a mouse model.

Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

The paper identifies a conserved mechanism, RePrESS, by which autoreactive innate-like T cells maintain tolerance through rewiring of the TCR signalosome.

The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection

This study shows that chronic Trypanosoma brucei infection in mice causes meningeal lymphoid aggregates with autoreactive B cells and autoantibodies against brain antigens.

Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

This study shows that Salmonella-based cancer therapy impairs T cell metabolism, which is linked to its anti-tumor effects.

Antigen and Checkpoint Receptor Recalibration of T Cell Receptor Signal Strength

This study identifies how TCR signal strength modulates CD4+ T cell function and shows that anti-PD1 therapy increases TCR signal strength, defining a metric to stratify melanoma patient outcomes.

Differential Nr4a1 and Nr4a3 expression discriminates tonic from activated TCR signalling events in vivo

The paper identifies differential Nr4a1 and Nr4a3 expression as markers distinguishing tonic from activating TCR signalling in T cells.

A Timer for analyzing temporally dynamic changes in transcription during differentiation in vivo

The paper introduces Tocky, a tool that reveals temporal dynamics of cellular differentiation in vivo by using a fluorescent timer protein and algorithms to track molecular processes.

A temporally dynamic Foxp3 autoregulatory transcriptional circuit controls the effector Treg programme

This study uses a Foxp3 Timer system to analyze Foxp3 transcription dynamics in Treg cells during immune responses, showing that persistent Foxp3 transcription drives effector Treg programs and can be modulated by immunotherapy.