IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic Trypanosoma brucei infection
M. C. Sinton, P. Chandrasegaran, P. Capewell…·J. F. Quintana Alcala
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6 papers
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M. C. Sinton, P. Chandrasegaran, P. Capewell…·J. F. Quintana Alcala
J. F. Quintana Alcala, M. C. Sinton, P. Chandrasegaran…·N. A. Mabbott
This study shows that chronic Trypanosoma brucei infection in mice causes meningeal lymphoid aggregates with autoreactive B cells and autoantibodies against brain antigens.
J. F. Q. Alcala, M. C. Sinton, P. Chandrasegaran…·A. MacLeod
This study uses spatial and single-cell transcriptomics to show that γδ T cells and adipocytes collaborate to control skin inflammation and adipose tissue wasting during chronic Trypanosoma brucei infection.
M. C. Sinton, B. Lucendo Villarin, J. Meseguer Ripolles…·A. J. Drake
This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.
M. C. Sinton, J. Meseguer-Ripolles, B. Lucendo-Villarin…·A. J. Drake
This study shows that NAFLD is linked to reduced mitochondrial respiration but not mitochondrial number or fragmentation in a human stem cell model.
K. J. Suchacki, A. A. S. Tavares, D. Mattiucci…·W. P. Cawthorn
This study identifies bone marrow adipose tissue (BMAT) as a distinct adipose subtype with unique metabolic functions in glucose homeostasis.