Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch
A. Balzulat, W. F. Zhu, C. Flauaus, V. Hernandez-Olmos, J. Heering, S. Sethumadhavan, M. Dubiel, A. Frank, A. Menge, M. Hebchen, K. Metzner, R. Lu, R. Lukowski, P. Ruth, S. Knapp, , A. Schmidtko
This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.
bioRxiv · Oct 5, 2023 · PreprintPharmacology & Toxicology