H. Stark

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.

Lattice-Boltzmann Modelling for Inertial Particle Microfluidics Applications -- A Tutorial Review

This paper reviews lattice-Boltzmann methods for simulating inertial particle microfluidics applications, providing a guide and case studies.

Structural characterization of human tryptophanhydroxylase 2 reveals L-Phe as the superior regulatorydomain ligand relevant for serotonin biosynthesis

This study determines the structure of TPH2's regulatory domain with L-Phe and shows it is a better ligand than L-Trp, revealing dynamic behavior in the tetramer.

Limb, joint and pelvic kinematic control in the quail coping with step perturbations

This study examines how common quails adjust their limb and pelvic kinematics to navigate step perturbations of varying heights.

A three-dimensional musculoskeletal model of the dog

The paper develops a 3D musculoskeletal model of dogs with 84 degrees of freedom and 134 muscles to study joint load and locomotion, validated using experimental data on forelimb muscle synergies.

Calculating the optimal hematocrit under the constraint of constant cardiac power

This paper calculates the optimal hematocrit under constant cardiac power, finding values between 0.5 and 0.7, which explains improved exertional performance at higher hematocrit.

Breaking the next Cryo-EM resolution barrier - Atomic resolution determination of proteins!

This paper reports a 1.25 Å resolution cryo-EM structure of apoferritin, achieving atomic-level detail and improving density map quality for drug design.

Tracking tendon fibers to their insertion - a 3D analysis of the Achilles tendon enthesis in mice

This study analyzes the 3D fiber structure of the Achilles tendon enthesis in mice to understand stress distribution and mechanical behavior.

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.