Author

J. Heering

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

E. Proschak· 2 shared S. Knapp· 2 shared S. Mueller· 2 shared A. Balzulat· 1 shared A. Frank· 1 shared A. Kumar· 1 shared A. Menge· 1 shared A. Schmidtko· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

E. Proschak

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2 papers

Recent·Most cited

Targeting LC3/GABARAP for degrader development and autophagy modulation

M. P. Schwalm, J. Dopfer, A. Kumar, F. A. Greco, N. Bauer, F. Loehr, J. Heering, S. Cano, S. Lechner, T. Hanke, I. Bekic, V. Morasch, D. Fearon, P. G. Marples, C. W. E. Tomlinson, , V. V. Rogov

The paper evaluates the druggability of LC3/GABARAP for autophagy modulators and identifies ligands that bind to the HP2 pocket of the LIR docking site.

bioRxiv · Oct 5, 2023 · PreprintBiochemistry

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

A. Balzulat, W. F. Zhu, C. Flauaus, V. Hernandez-Olmos, J. Heering, S. Sethumadhavan, M. Dubiel, A. Frank, A. Menge, M. Hebchen, K. Metzner, R. Lu, R. Lukowski, P. Ruth, S. Knapp, , A. Schmidtko

This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.

bioRxiv · Oct 5, 2023 · PreprintPharmacology & Toxicology