Author

R. Lukowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1

Frequent Co-Authors

H. Bischof· 2 shared R. Malli· 2 shared S. Burgstaller· 2 shared A. Balzulat· 1 shared A. Frank· 1 shared A. L. Birkenfeld· 1 shared A. Menge· 1 shared A. Padamsey· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

H. Bischof

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

A. Balzulat, W. F. Zhu, C. Flauaus, V. Hernandez-Olmos, J. Heering, S. Sethumadhavan, M. Dubiel, A. Frank, A. Menge, M. Hebchen, K. Metzner, R. Lu, R. Lukowski, P. Ruth, S. Knapp, , A. Schmidtko

This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.

bioRxiv · Oct 5, 2023 · PreprintPharmacology & Toxicology

mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming

H. Bischof, S. Maier, P. Koprowski, B. Kulawiak, S. Burgstaller, J. Jasinska, K. Serafimov, M. Zochowska, D. Gross, W. Schroth, L. Matt, D. A. Juarez Lopez, Y. Zhang, I. Bonzheim, F. A. Büttner, , R. Lukowski

This study identifies mitoBKCa, a BKCa splice variant in mitochondria of breast cancer cells, showing it modulates energy production and promotes proliferation, suggesting it as a potential therapeutic target.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors

S. Burgstaller, T. R. Wagner, H. Bischof, S. Bueckle, A. Padamsey, D. I. Frecot, P. D. Kaiser, D. Skrabak, R. Malli, R. Lukowski, U. Rothbauer

This study develops recombinant nanobody-fused biosensors to monitor extracellular K+, pH, and glucose in real time, demonstrating their utility in cancer and neuronal cells.

bioRxiv · Apr 12, 2022Biochemistry