Author

M. Henault

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Organism:yeast· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Fijarczyk· 2 shared G. Charron· 2 shared S. Marsit· 2 shared A. Hofmann· 1 shared A. Vulpetti· 1 shared B. Bauer-Probst· 1 shared B. Chung· 1 shared B. Pinch· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersEvolutionary Biology

A. Fijarczyk

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Author profile →

3 papers

Recent·Most cited

Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings

M. Schroeder, M. Renatus, X. Liang, F. Meili, S. Ferrand, F. Gauter, X. Li, F. Sigoillot, S. Gleim, M.-T. Stachyra, J. Thomas, M. Schirle, T. Zoller, D. Begue, P. Lefeuvre, , C. R. Thoma

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

bioRxiv · Apr 9, 2023 · PreprintBiochemistry

Heterogeneous mutation rates and spectra in yeast hybrids

A. Fijarczyk, M. Henault, S. Marsit, G. Charron, C. R. Landry

The paper examines mutation rates and spectra in yeast hybrids, finding significant variation among crosses that is genotype-specific rather than related to parental divergence.

bioRxiv · Jun 4, 2021Evolutionary Biology

The rate of whole-genome duplication can be accelerated by hybridization

S. Marsit, C. Landry, M. Henault, G. Charron, A. Fijarczyk

This study shows hybridization can trigger whole-genome duplication (WGD) in yeast, increasing fertility and genetic variability, and that some genotypes are more prone to WGD.

bioRxiv · Oct 14, 2020 · PreprintEvolutionary Biology