Author

M. Holwerda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. Dijkman· 8 shared L. Laloli· 6 shared P. V'kovski· 6 shared V. Thiel· 6 shared J. Portmann· 5 shared M. Wider· 5 shared A. Kratzel· 4 shared H. Stalder· 4 shared

Activity by Year

2019-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersMicrobiology

R. Dijkman

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Emergence of bluetongue virus serotype 3 in the Netherlands in September 2023

M. Holwerda, I. Santman-Berends, F. Harders, M. Y. Engelsma, R. Vloet, E. Dijkstra, R. van Gennip, J. Mars, M. Spierenburg, L. Roos, R. van den Brom, P. van Rijn

A Bluetongue virus serotype 3 outbreak was detected in the Netherlands in September 2023, affecting sheep and cattle, with no prior circulation identified.

bioRxiv · Sep 29, 2023Microbiology

Establishment of a reverse genetic system from a bovine derived Influenza D virus isolate.

M. Holwerda, L. Laloli, M. Wider, L. Schoenecker, J. Becker, M. Meylan, R. Dijkman

This paper establishes a reverse genetic system for a bovine Influenza D virus isolate to study its host tropism.

bioRxiv · Feb 10, 2021Microbiology

Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2

M. Gultom, M. Licheri, L. Laloli, M. Wider, M. Straessle, S. Steiner, A. Kratzel, T. T. N. Thao, H. Stalder, J. Portmann, M. Holwerda, P. V'kovski, N. Ebert, N. Stokar - Regenscheit, C. Gurtner, , R. Dijkman

This study assesses the susceptibility of airway epithelial cell cultures from various animals to SARS-CoV-2, finding efficient replication only in monkey and cat models.

bioRxiv · Nov 10, 2020 · PreprintMicrobiology

Identification of five antiviral compounds from the Pandemic Response Box targeting SARS-CoV-2

M. Holwerda, P. V'kovski, M. Wider, V. Thiel, R. Dijkman

This study screens 400 compounds from the Pandemic Response Box and identifies five with antiviral activity against SARS-CoV-2, including some more effective than Remdesivir.

bioRxiv · May 17, 2020 · PreprintMicrobiology

Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

P. V'kovski, M. Gultom, J. N. Kelly, S. Steiner, J. Russeil, B. Mangeat, E. Cora, J. Pezoldt, M. Holwerda, A. Kratzel, L. Laloli, M. Wider, J. Portmann, T. T. N. Thao, N. Ebert, , R. Dijkman

This study compares temperature-dependent replication and immune response dynamics of SARS-CoV-2 and SARS-CoV in human airway epithelial cells, highlighting differences in their antiviral responses and transmission efficiency.

bioRxiv · Apr 27, 2020Microbiology

Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis.

J. N. Kelly, L. Laloli, P. V'kovski, M. Holwerda, J. Portmann, V. Thiel, R. Dijkman

This study uses scRNA-seq to analyze IAV infection in human airway epithelial cells, revealing cell-type specific host responses and viral tropism shifts.

bioRxiv · Apr 3, 2020 · PreprintMicrobiology

Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols

A. Kratzel, D. Todt, P. V'kovski, S. Steiner, M. L. Gultom, T. T. N. Thao, N. Ebert, M. Holwerda, J. Steinmann, D. Niemeyer, R. Dijkman, G. Kampf, C. Drosten, E. Steinmann, V. Thiel, S. Pfaender

The paper tests the virucidal activity of WHO-recommended hand rubs and alcohols against SARS-CoV-2, showing efficient inactivation for all tested products.

bioRxiv · Mar 10, 2020 · PreprintMicrobiology

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

T. T. N. Thao, F. Labroussaa, N. Ebert, P. V'kovski, H. Stalder, J. Portmann, J. Kelly, S. Steiner, M. Holwerda, A. Kratzel, M. Gultom, L. Laloli, L. Huesser, M. Wider, S. Pfaender, , V. Thiel

This paper describes a yeast-based synthetic genomics platform for rapid reconstruction of RNA viruses, including SARS-CoV-2, using synthetic DNA fragments and TAR cloning.

bioRxiv · Feb 21, 2020Microbiology

Determining the replication kinetics and cellular tropism of the ruminant-associated Influenza D virus on primary human airway epithelial cells

M. Holwerda, L. Laloli, I. Stuermer, J. Portmann, H. Stalder, R. Dijkman

This study investigates the replication and cell tropism of Influenza D virus in human airway epithelial cells, finding efficient replication and ciliated cell tropism similar to Influenza C virus.

bioRxiv · Jan 3, 2019Microbiology