Author

S. Kusakabe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. Sato· 3 shared H. Nobori· 3 shared H. Sawa· 3 shared K. Tabata· 3 shared M. Sasaki· 3 shared S. Toba· 3 shared T. Suzuki· 3 shared W. W. Hall· 3 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

A. Sato

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in severe COVID-19

M. Sasaki, S. Iida, Y. Hirata, S. Kusakabe, K. Konishi, Y. Itakura, K. Tabata, M. Kishimoto, H. Kobayashi, T. Ariizumi, K. Intaruck, H. Nobori, S. Toba, A. Sato, K. Matsuno, , H. Sawa

This study shows that combining an oral antiviral with a corticosteroid improves treatment outcomes in delayed SARS-CoV-2 infection in hamsters compared to monotherapy.

bioRxiv · Jun 20, 2023Microbiology

2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses

K. Uemura, H. Nobori, A. Sato, S. Toba, S. Kusakabe, M. Sasaki, K. Tabata, K. Matsuno, N. Maeda, S. Ito, M. Tanaka, Y. Anraku, S. Kita, M. Ishii, K. Kanamitsu, , K. Maenaka

This study identifies 2-thiouridine as a broad-spectrum antiviral against SARS-CoV-2 and other positive-strand RNA viruses by inhibiting viral RNA synthesis.

bioRxiv · Dec 14, 2022Microbiology

Oral administration of S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and accelerates recovery from clinical aspects of COVID-19

M. Sasaki, K. Tabata, M. Kishimoto, Y. Itakura, H. Kobayashi, T. Ariizumi, K. Uemura, S. Toba, S. Kusakabe, Y. Maruyama, S. Iida, N. Nakajima, T. Suzuki, S. Yoshida, H. Nobori, , H. Sawa

This study shows that oral S-217622 reduces SARS-CoV-2 viral load and improves recovery in hamsters, with activity against multiple variants.

bioRxiv · Feb 14, 2022Microbiology

Extreme genetic signatures of local adaptation during plant colonization

N. Shah, T. Wakabayashi, Y. Kawamura, C. K. Skovbjerg, M.-Z. Wang, Y. Mustamin, Y. Isomura, V. Gupta, H. Jin, T. Mun, N. Sandal, F. Azuma, E. Fukai, U. Seren, S. Kusakabe, , S. U. Andersen

The paper investigates genetic adaptations during the colonization of Japan by Lotus japonicus, identifying genomic regions and candidate genes associated with overwintering and flowering time traits.

bioRxiv · Dec 11, 2018Evolutionary Biology

USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation

S. Kusakabe, T. Suzuki, Y. Sugiyama, S. Haga, K. Horike, M. Tokunaga, J. Hirano, Z. He, D. V. Chen, H. Ishiga, Y. Komoda, C. Ono, T. Fukuhara, M. Yamamoto, M. Ikawa, , Y. Matsuura

This study identifies USP15 as a host factor for HCV propagation, showing it regulates viral RNA translation and lipid droplet formation in hepatic cells.

bioRxiv · Oct 2, 2018Microbiology