Author

M. J. Dahl

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Biophysics· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

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H. Yang· 1 shared J. K. Machhi· 1 shared M. F. Mecha· 1 shared S. C. Carey· 1 shared Silvia Cavagnero· 1 shared X. Chen· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiophysics

H. Yang

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1 paper

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BiophysicsbioRxivPreprintNov 10, 2026

Unavoidable Disasters: the Hsp70 Chaperone Can Only Prevent Aggregation Over a Limited Time Span

M. F. Mecha, M. J. Dahl, J. K. Machhi…·Silvia Cavagnero

The paper develops a computational model to show that Hsp70 chaperones only delay, not prevent, protein aggregation, depending on client-specific kinetic and thermodynamic properties.

DOI 10.64898/2026.11.09.765239

E. coliprotein structure

𝕏 PostBluesky