M. J. Gaudry

The paper identifies a cold-inducible truncated Adcy3 mRNA isoform, Adcy3-at, which acts as a rheostat to regulate brown fat function by limiting cAMP activity during obesity.

The paper tests senescence predictions in wild lake trout, finding negligible senescence when maximum size is only slightly larger than maturation size, and potential negative senescence in populations with larger maximum sizes.

The paper shows that inactivation of UCP1 occurred in multiple placental mammal clades and is linked to reduced metabolic intensity and increased body mass during periods of global cooling.