Author

O. Patel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

I. Lucet· 2 shared J. Hou· 2 shared M. J. Roy· 2 shared R. J. Daly· 2 shared X. Ma· 2 shared A. Behren· 1 shared A. Boussioutas· 1 shared A. Chung· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

I. Lucet

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Vgamma9Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

T. S. Fulford, C. Soliman, R. G. Castle, M. Rigau, Z. Ruan, O. Dolezal, R. Seneviratna, H. G. Brown, E. Hanssen, A. Hammet, S. Li, S. J. Redmond, A. Chung, M. A. Gorman, M. W. Parker, , A. P. Uldrich

The paper reveals that Vgamma9Vdelta2 T cells recognize BTN2A1 and BTN3A1 heteromers through dual epitope engagement, uncovering a new mechanism of immune activation.

bioRxiv · Aug 30, 2023Immunology

When two is a crowd - Structural mapping of PEAK pseudokinase interactions identifies 14 3 3 as a molecular switch for PEAK3/Crk signaling.

M. J. Roy, M. G. Surudoi, A. Kropp, J. Hou, W. Dai, J. M. Hardy, L.-Y. Liang, T. R. Cotton, B. C. Lechenberg, T. A. Dite, X. Ma, R. J. Daly, O. Patel, I. Lucet

The paper identifies 14-3-3 as a molecular switch for PEAK3/Crk signaling by mapping PEAK pseudokinase interactions and demonstrating a conserved high affinity 14-3-3 motif.

bioRxiv · Sep 1, 2022 · PreprintBiochemistry

The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscape

S. Afshar-Sterle, A. L. E. Carli, R. O'Keefe, J. Tse, S. Fischer, A. I. Azimpour, D. Baloyan, L. Elias, P. Thilakasiri, O. Patel, F. M. Ferguson, M. F. Eissmann, A. L. Chand, N. S. Gray, R. Busuttil, , M. Buchert

This study identifies DCLK1 kinase activity as a driver of gastric cancer progression by reprogramming the tumor stroma and promoting invasiveness and metastasis.

bioRxiv · Apr 21, 2022 · PreprintCancer Biology

PEAK3 pseudokinase represents a pro-migratory and -invasive signalling scaffold

J. Hou, E. V. Nguyen, M. Surudoi, M. J. Roy, O. Patel, I. S. Lucet, X. Ma, R. J. Daly

This study identifies PEAK3 as a pseudokinase that promotes cell migration and invasion through scaffolding interactions and tyrosine phosphorylation.

bioRxiv · Feb 17, 2021 · PreprintCancer Biology