M. J. Tuvim

The paper shows that CpG ODNs interact with mitochondrial VDAC1 to induce antimicrobial ROS in lung epithelial cells, offering a new therapeutic strategy for pneumonia without antibiotics.

Aerosolized Toll-like receptor agonists reduce allergic inflammation in mice by modulating airway epithelial cell responses to allergens.

This study tests if modulating TMEM16A channel function affects airway goblet cells or smooth muscle function, finding no significant effects.

The paper shows that Pam2-ODN treatment improves survival in mice infected with a paramyxovirus by reducing viral burden and blocking CD8+ T cell-driven inflammation.

This study shows that Pam2-ODN treatment improves survival in mice with Sendai virus pneumonia by inactivating the virus and reducing CD8+ T cell-mediated inflammation.

The paper identifies distinct roles of Munc18 isoforms in baseline and stimulated airway mucin secretion, showing Munc18b's protective role in asthma and cystic fibrosis models.

This study identifies Munc13-4 as essential for mast cell regulated exocytosis and IgE-mediated anaphylaxis, while Munc13-2 plays a minor role.