M. K. Levings

The paper maps sex differences in thymic niches using spatial multi-omics to reveal how sex influences T cell development and immune function.

This study shows that A2-CAR T cells can reject HLA-A2+ human islets in mice without causing graft-versus-host disease, enabling the study of islet rejection mechanisms.

This paper demonstrates that InsB-g7 CAR Tregs specific for an insulin B-chain peptide prevent autoimmune diabetes in NOD mice.

This study compares CAR-Treg function with different co-stimulatory domains, finding in vivo equivalence between CARs with and without CD28 despite in vitro differences.

This study shows PTEN is not essential for general Treg function but is required for their ability to suppress costimulatory molecule expression by antigen-presenting cells.

The paper shows that Helios expression marks, but does not drive, human Treg stability in vitro, using CRISPR/Cas9 and in vitro expansion systems.

This study optimizes CRISPR-mediated gene knock-in in human Tregs and shows FOXP3 has a limited role in maintaining mature Treg identity.

This study shows that human regulatory T cells (Tregs) can become exhausted through repetitive stimulation or tonic-signaling CARs, reducing their suppressive function in vivo.

This study compares ten CAR signaling domains in Tregs, finding that wild-type CD28 CARs are most effective in suppressing graft-versus-host disease.