Author

M. Mojibian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. K. Levings· 5 shared M. Speck· 3 shared V. Fung· 3 shared C. M. Wardell· 2 shared E. McIver· 2 shared M. Haque· 2 shared P. C. Orban· 2 shared A. J. Dwyer· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

M. K. Levings

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Author profile →

5 papers

Recent·Most cited

Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease

C. E. Ellis, M. Mojibian, V. C. W. Fung, S. Skovso, E. McIver, S. ODwyer, T. D. Webber, M. J. S. Braam, S. Ida, N. Saber, T. J. Kieffer, M. K. Levings

This study shows that A2-CAR T cells can reject HLA-A2+ human islets in mice without causing graft-versus-host disease, enabling the study of islet rejection mechanisms.

bioRxiv · Feb 23, 2023Immunology

Insulin B peptide-MHC class II-specific chimeric antigen 1 receptor-Tregs prevent autoimmune diabetes

J. A. Spanier, V. Fung, C. M. Wardell, M. H. Alkhatib, Y. Chen, L. A. Swanson, A. J. Dwyer, M. E. Weno, N. Silva, J. S. Mitchell, P. C. Orban, M. Mojibian, C. B. Verchere, B. T. Fife, M. K. Levings

This paper demonstrates that InsB-g7 CAR Tregs specific for an insulin B-chain peptide prevent autoimmune diabetes in NOD mice.

bioRxiv · Feb 23, 2023 · PreprintImmunology

Integration of exogenous and endogenous co-stimulatory signals by CAR-Tregs

I. Rosado-Sanchez, M. Haque, K. Salim, M. Speck, V. Fung, D. Boardman, M. Mojibian, G. Raimondi, M. K. Levings

This study compares CAR-Treg function with different co-stimulatory domains, finding in vivo equivalence between CARs with and without CD28 despite in vitro differences.

bioRxiv · Nov 10, 2022 · PreprintImmunology

PTEN is required for human Treg suppression of costimulation

A. J. Lam, M. Haque, K. A. Ward-Hartstonge, P. Uday, C. M. Wardell, J. K. Gillies, M. Speck, M. Mojibian, R. I. K. Geltink, M. K. Levings

This study shows PTEN is not essential for general Treg function but is required for their ability to suppress costimulatory molecule expression by antigen-presenting cells.

bioRxiv · Mar 6, 2022 · PreprintImmunology

Functional effects of chimeric antigen receptor co-receptor signaling domains in human Tregs

N. A. Dawson, I. Rosado Sanchez, G. Novakovsky, V. Fung, Q. Huang, E. McIver, G. Sun, J. Gillies, M. Speck, P. C. Orban, M. Mojibian, M. K. Levings

This study compares ten CAR signaling domains in Tregs, finding that wild-type CD28 CARs are most effective in suppressing graft-versus-host disease.

bioRxiv · Aug 29, 2019Immunology