MicrobiologybioRxiv
Structural basis for PoxtA-mediated resistance to Phenicol and Oxazolidinone antibiotics
C. Crowe-McAuliffe, V. Murina, M. Kasari…·V. Hauryliuk
This paper presents cryo-EM structures of PoxtA bound to the ribosome, revealing its mechanism of antibiotic resistance by perturbing tRNA and altering nascent chain conformation.
DOI 10.1038/s41467-022-29274-9