Author

M. Kirchenwitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Steffen· 3 shared K. Rottner· 2 shared S. Prettin· 2 shared T. E. B. Stradal· 2 shared T. Stradal· 2 shared B. M. Kemkuignou· 1 shared C. Birchmeier· 1 shared C. Chepkirui· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

A. Steffen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RhoB promotes Salmonella survival by regulating autophagy

M. Kirchenwitz, J. Halfen, K. von Peinen, S. Prettin, J. Kollasser, C. H. Brakebusch, K. Rottner, A. Steffen, T. Stradal

This study shows RhoB promotes Salmonella survival by enhancing autophagy, which is regulated by the bacterial effector SopB.

bioRxiv · Apr 5, 2023 · PreprintCell Biology

Neurotrophic and immunomodulatory lanostane triterpenoids from wood-inhabiting Basidiomycota

K. Hassan, B. M. Kemkuignou, M. Kirchenwitz, K. Wittstein, M. Rascher, C. Chepkirui, J. C. Matasyoh, C. Decock, R. Koester, T. E. B. Stradal, M. Stadler

This study identifies lanostane triterpenoids from medicinal mushrooms that enhance neurotrophic factors ngf and bdnf without cytotoxicity, suggesting potential for neurodegenerative disease treatment.

bioRxiv · Oct 27, 2022Biochemistry

SMER28 attenuates PI3K/mTOR signaling by direct inhibition of PI3K p110 delta

M. Kirchenwitz, S. Stahnke, S. Prettin, M. Borowiak, C. Birchmeier, K. Rottner, T. E. B. Stradal, A. Steffen

The paper identifies SMER28 as a compound that inhibits PI3K p110 delta and disrupts receptor tyrosine kinase signaling, leading to autophagy induction and reduced cell growth.

bioRxiv · Dec 10, 2021Cell Biology

Crystal structure of full-length cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication

P. Chaoprasid, P. Lukat, S. Mühlen, T. V. Heidler, E. M. Gazdag, S. Dong, W. Bi, C. Rueter, M. Kirchenwitz, A. Steffen, L. Jansch, T. Stradal, P. Dersch, W. Blankenfeldt

The paper determines the crystal structure of CNFY, revealing domains involved in toxin translocation and identifying its potential as a drug delivery tool.

bioRxiv · Apr 7, 2020Biochemistry