K. Rottner

RhoB promotes Salmonella survival by regulating autophagy

This study shows RhoB promotes Salmonella survival by enhancing autophagy, which is regulated by the bacterial effector SopB.

ArpC5 isoforms regulate Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning

The paper investigates how ArpC5 and ArpC5L isoforms regulate cell migration by affecting Arp2/3 complex function and Ena/VASP positioning, linking them to cancer progression.

Arf GTPase activates the WAVE Regulatory Complex through a novel binding site

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

Ena/VASP clustering at microspike tips involves Lamellipodin but not I-BAR proteins, and absolutely requires unconventional Myosin-X

This study identifies unconventional Myosin-X as essential for Ena/VASP clustering and microspike formation, while showing Lamellipodin is involved but inverse BAR-domain proteins are not.

Structures reveal a key mechanism of WAVE Regulatory Complex activation by Rac1 GTPase

The paper reports WAVE Regulatory Complex structures bound to Rac1, revealing how Rac1 binding at the A site activates WRC to drive actin polymerization.

SMER28 attenuates PI3K/mTOR signaling by direct inhibition of PI3K p110 delta

The paper identifies SMER28 as a compound that inhibits PI3K p110 delta and disrupts receptor tyrosine kinase signaling, leading to autophagy induction and reduced cell growth.

Lamellipodia-like actin networks in cells lacking WAVE Regulatory Complex

The paper shows that lamellipodia-like structures can form without the WAVE Regulatory Complex by using Rac and Cdc42, but not Ena/VASP family proteins.

Loss of Hem1 disrupts macrophage function and impacts on migration, phagocytosis and integrin-mediated adhesion

This study shows that Hem1 deficiency impairs macrophage migration, phagocytosis, and integrin-mediated adhesion by disrupting WRC function and paxillin phosphorylation.

A structure-derived mechanism reveals how capping protein promotes nucleation in branched actin networks

This study reveals how capping protein (CP) promotes nucleation in branched actin networks by controlling access to terminal actin subunits and inhibiting nucleation promoting factors.

Induced Arp2/3 complex depletion increases FMNL2/3 formin expression and filopodia formation

This study shows that acute Arp2/3 complex depletion increases FMNL2/3 formin expression and filopodia formation in fibroblasts, despite reduced actin turnover and impaired lamellipodia formation.

Dendritic cell actin dynamics controls T cell priming efficiency at the immunological synapse

This study shows that dendritic cell actin dynamics, regulated by the WAVE complex, influence T cell priming efficiency at the immunological synapse by modulating synaptic structure and adhesion.

Global mapping of Salmonella enterica-host protein-protein interactions during infection

The paper maps Salmonella enterica effector-host protein-protein interactions during infection, identifying 421 novel interactions and demonstrating their roles in pathogenesis.

Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation

This study shows that lamellipodin stabilizes protrusions and promotes adhesion formation, enhancing cell migration efficiency.

Amplitude Analysis of Polarization Modulation Data and 3D-Polarization Demodulation (3D-SPoD)

This paper analyzes the amplitude of polarization modulation data in 3D-SPoD to improve structure reconstruction and reduce background noise in super-resolution imaging.

Molecular dissection of neurodevelopmental disorder-causing mutations in CYFIP2

This study investigates CYFIP2 mutations in neurodevelopmental disorders, showing most cause constitutive WRC activation, while some are loss-of-function or have minimal effects.

Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

This study shows that Ena/VASP proteins promote cell migration by regulating lamellipodium architecture, actin dynamics, and integrin-dependent adhesion.

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation, which controls pseudopod lifetime

The paper shows that cell-substrate adhesion drives Scar/WAVE phosphorylation, which limits pseudopod lifetime, independent of chemotactic signals.

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE Regulatory Complex-binding

This study shows RhoG and Cdc42 can drive lamellipodia formation independently of Rac by directly interacting with the WAVE Regulatory Complex.