S. Dong

Ancient cyanobacterial proto-circadian clock adapted to short day-night cycles ~ 0.95 billion years ago

The paper reconstructs an ancient cyanobacterial circadian clock from ~0.95 billion years ago and shows it adapts to 18-h day-night cycles but lacks endogenous oscillation.

SBT5.2s are the major active extracellular subtilases processing IgG antibody 2F5 in the Nicotiana benthamiana apoplast

The paper shows that SBT5.2 subtilases degrade the IgG antibody 2F5 in Nicotiana benthamiana apoplast, and their knockout increases 2F5 accumulation without affecting plant growth.

In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies

This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.

Does bumblebee preference of continuous over interrupted strings in string-pulling tasks indicate means-end comprehension?

This study investigates whether bumblebees use means-end comprehension in string-pulling tasks and finds they rely on visual matching and associative learning instead.

Optimising a self-assembling peptide hydrogel as a Matrigel alternative for 3-dimensional mammary epithelial cell culture

This study optimizes self-assembling peptide hydrogels to better support mammary epithelial cell organoid formation compared to Matrigel.

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential

This study evaluates the antiviral efficacy of GS-5245 against multiple SARS-CoV-2 variants and other coronaviruses, showing broad in vitro activity and protective effects in animal models.

Alternative splicing of a potato disease resistance gene maintains homeostasis between development and immunity

The paper shows that the potato resistance gene RB uses alternative splicing to balance growth and immunity, with the pathogen effector IPI-O1 promoting splicing to enhance immunity.

Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion Loop

This study engineers DENV variants with mutated fusion loops that evade neutralizing antibodies but retain sensitivity to cross-reactive antibodies, offering tools for vaccine development.

DNA damage-induced YTHDC1 O-GlcNAcylation promotes homologous recombination by enhancing N6-methyladenosine binding

This study shows that DNA damage-induced O-GlcNAcylation of YTHDC1 enhances its m6A binding, promoting homologous recombination and genome stability.

Multimodal electrocorticogram active electrode array based on zinc oxide-thin film transistors

This paper develops a transparent active ECoG array using ZnO-TFTs for electrophysiological monitoring, enabling simultaneous optical and MRI-compatible brain signal recording.

A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated Oligonucleotides

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

Genome-wide analyses of histone modifications and chromatin accessibility reveal the distinct genomic compartments in the Irish potato famine pathogen Phytophthora infestans

The paper analyzes histone modifications and chromatin accessibility in Phytophthora infestans to reveal distinct genomic compartments and their association with virulence factor genes.

A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

This paper develops a murine model of persistent post-SARS-CoV-2 lung disease to identify therapeutic targets and test interventions for PASC.

Making Plants Smell Like Moths: Nicotiana benthamiana release moth pheromone alcohol, aldehyde and acetate upon transient expression of biosynthetic genes of different origin

The paper demonstrates that Nicotiana benthamiana can produce moth pheromone components when expressing biosynthetic genes from different origins.

Screening and Identification of Lujo Virus Entry Inhibitors from an FDA-Approved Drugs Library

This study identifies three FDA-approved drugs that inhibit Lujo virus entry by targeting the envelope glycoprotein's transmembrane domain and calcium channels.

Screening of Botanical Drugs against SARS-CoV-2 Entry

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

Genetically Engineered DENV Produces Antigenically Distinct Mature Particles

This study genetically engineers DENV to produce antigenically distinct mature particles, offering new tools for vaccine development and maturation studies.

An HB40 - JUNGBRUNNEN1 - GA 2-OXIDASE regulatory module for gibberellin homeostasis in Arabidopsis

This study identifies a regulatory module involving HB40, JUB1, GA2ox, and DELLA proteins that controls gibberellin homeostasis in Arabidopsis by modulating GA biosynthesis, deactivation, and signaling.

Spatio-temporal evolution of urban thermal environment and its driving factors: Case study of Nanjing, China

This study analyzes the spatio-temporal changes in Nanjing's urban thermal environment from 2014 to 2018 and identifies key driving factors behind these changes.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

Numerical Model for Formation and Evolution of the Bleb

This paper develops a numerical model to simulate bleb formation and evolution in cells, showing how parameters affect bleb size and shape.

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

Crystal structure of full-length cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication

The paper determines the crystal structure of CNFY, revealing domains involved in toxin translocation and identifying its potential as a drug delivery tool.

Glucose-mediated expansion of a gut commensal bacterium promotes Plasmodium infection through alkalizing mosquito midgut

The paper shows dietary glucose promotes Plasmodium infection by expanding a gut bacterium that alkalizes mosquito midgut, enhancing parasite development.

Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

This paper identifies centromeres in Phytophthora sojae using long-read sequencing and ChIP-seq, revealing transposon-rich, heterochromatic regions distinct from other SAR supergroup organisms.

Cleavage of a pathogen apoplastic protein by plant subtilases activates immunity

This study shows that cleavage of a pathogen protein by plant proteases activates immunity, while pathogens counteract this with inhibitors.

Antibody-free enzyme-assisted chemical labeling for detection of transcriptome-wide N6-methyladenosine

This paper introduces an antibody-free method for transcriptome-wide m6A detection using FTO-assisted chemical labeling, showing good sensitivity and overlap with antibody-based results.

Overexpression of long noncoding RNA GAS5 suppresses tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mToR pathway

This study shows that overexpressing lncRNA GAS5 suppresses gastric cancer by inhibiting miR-106a-5p, which activates the Akt/mToR pathway.