A. Steffen

Phosphorylation Promotes Liquid-Liquid Phase Separation of GRP8 and Its Assembly into Stress Granules Upon Salinity Stress in Arabidopsis

Novel YAP1/TAZ pathway inhibitors identified through phenotypic screening with potent anti-tumor activity via blockade of GGTase-I / Rho-GTPase signaling

RhoB promotes Salmonella survival by regulating autophagy

This study shows RhoB promotes Salmonella survival by enhancing autophagy, which is regulated by the bacterial effector SopB.

SMER28 attenuates PI3K/mTOR signaling by direct inhibition of PI3K p110 delta

The paper identifies SMER28 as a compound that inhibits PI3K p110 delta and disrupts receptor tyrosine kinase signaling, leading to autophagy induction and reduced cell growth.

Lamellipodia-like actin networks in cells lacking WAVE Regulatory Complex

The paper shows that lamellipodia-like structures can form without the WAVE Regulatory Complex by using Rac and Cdc42, but not Ena/VASP family proteins.

Loss of Hem1 disrupts macrophage function and impacts on migration, phagocytosis and integrin-mediated adhesion

This study shows that Hem1 deficiency impairs macrophage migration, phagocytosis, and integrin-mediated adhesion by disrupting WRC function and paxillin phosphorylation.

Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators EGR2 and SOX2 in Tumorigenesis

RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of Quiescence

The paper identifies novel regulators of quiescence in colon cancer stem cells using RNA-sequencing and shows their potential as therapeutic targets.

Induced Arp2/3 complex depletion increases FMNL2/3 formin expression and filopodia formation

This study shows that acute Arp2/3 complex depletion increases FMNL2/3 formin expression and filopodia formation in fibroblasts, despite reduced actin turnover and impaired lamellipodia formation.

Crystal structure of full-length cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication

The paper determines the crystal structure of CNFY, revealing domains involved in toxin translocation and identifying its potential as a drug delivery tool.

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE Regulatory Complex-binding

This study shows RhoG and Cdc42 can drive lamellipodia formation independently of Rac by directly interacting with the WAVE Regulatory Complex.

Visualization and regulation of translocons in Yersinia type III protein secretion machines during host cell infection

This study visualizes Yersinia translocons during host infection using superresolution microscopy and shows their regulation by host factors like Rac1.