Actin dynamics regulation by TTC7A/PI4KIIIα axis limits DNA damage and cell death during leukocyte migration
T. Gajardo, M. Lo, M. Bernard, C. Leveau, M.-T. El-Daher, M. Kurowska, G. Le Lay, D. Moshous, B. Neven, A. Fischer, G. Menasche, G. de Saint Basile, P. Vargas, F. E. Sepulveda
This study shows TTC7A deficiency impairs leukocyte migration, leading to DNA damage and cell death during chemotaxis in dense environments.
bioRxiv · Oct 14, 2021 · PreprintImmunology