Eastern Equine Encephalitis Virus Rapidly Infects and Disseminates in the Brain and Spinal Cord of Infected Cynomolgus Macaques Following Aerosol Challenge
J. A. Williams, S. Y. Long, X. Zeng, K. Kuehl, A. M. Babka, N. M. Davis, J. Liu, J. C. Trefry, S. Daye, P. R. Facemire, P. L. Iversen, S. Bavari, M. L. Pitt, F. Nasar
This study investigates EEEV pathogenesis in cynomolgus macaques following aerosol challenge, finding that the virus replicates in the olfactory bulb and spreads via axonal transport, causing neuronal dysfunction rather than death.
bioRxiv · Dec 21, 2020Microbiology