Author

S. Bavari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:non-human primate· 3 Organism:mouse· 2 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

F. Nasar· 5 shared S. Lederman· 3 shared A. Macaluso· 2 shared B. Daugherty· 2 shared J. C. Trefry· 2 shared M. Awasthi· 2 shared M. L. Pitt· 2 shared R. S. Noyce· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

F. Nasar

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Recombinant chimeric Horsepox Virus (TNX-801) is attenuated relative to Vaccinia Virus Strains in Human Primary Cell Lines and in Immunocompromised Mice

S. Trefry, C. Raney, A. Cregger, N. Martinez, B. Layton, R. Enamorado, D. Gohegan, T. Moulaei, N. Ziolkowska, S. Goebel, S. Lederman, S. Bavari, F. Nasar

This study compares the attenuation of TNX-801, a recombinant chimeric Horsepox virus, to VACV-based vaccines in cell lines and mice, showing TNX-801 is significantly more attenuated.

bioRxiv · Oct 25, 2023 · PreprintMicrobiology

Immunogenicity and Efficacy of TNX-1800, A Live Virus Recombinant Poxvirus Vaccine Candidate, Against SARS-CoV-2 Challenge in Nonhuman Primates

M. Awasthi, A. Macaluso, D. Myscofski, J. Prigge, F. Koide, R. S. Noyce, S. Fogarty, H. Stillwell, S. J. Goebel, B. Daugherty, F. Nasar, S. Bavari, S. Lederman

This study evaluates the immunogenicity and efficacy of TNX-1800, a poxvirus vaccine expressing SARS-CoV-2 spike protein, in nonhuman primates challenged with SARS-CoV-2.

bioRxiv · Sep 19, 2023Immunology

Immunogenicity and tolerability of a SARS-CoV-2 TNX-1800, a live recombinant poxvirus vaccine candidate, in Syrian Hamsters and New Zealand White Rabbits.

M. Awasthi, A. Macaluso, S. J. Goebel, E. Luea, R. S. Noyce, F. Nasar, B. Daugherty, S. Bavari, S. Lederman

This study evaluates the immunogenicity and tolerability of the SARS-CoV-2 vaccine TNX-1800 in hamsters and rabbits, finding it well-tolerated with undetectable viral load after 28 days.

bioRxiv · Sep 6, 2023Immunology

Eastern Equine Encephalitis Virus Rapidly Infects and Disseminates in the Brain and Spinal Cord of Infected Cynomolgus Macaques Following Aerosol Challenge

J. A. Williams, S. Y. Long, X. Zeng, K. Kuehl, A. M. Babka, N. M. Davis, J. Liu, J. C. Trefry, S. Daye, P. R. Facemire, P. L. Iversen, S. Bavari, M. L. Pitt, F. Nasar

This study investigates EEEV pathogenesis in cynomolgus macaques following aerosol challenge, finding that the virus replicates in the olfactory bulb and spreads via axonal transport, causing neuronal dysfunction rather than death.

bioRxiv · Dec 21, 2020Microbiology

The Utilization of Advance Telemetry to Investigate Important Physiological Parameters Including Electroencephalography in Cynomolgus Macaques Following Aerosol Challenge with Eastern Equine Encephalitis Virus

J. C. Trefry, F. D. Rossi, M. Accardi, B. Dorsey, T. R. Sprague, S. E. Wollen-Roberts, J. D. Shamblin, A. E. Kimmel, P. J. Glass, L. Miller, A. P. Cardile, D. R. Smith, S. Bavari, S. Authier, W. D. Pratt, , F. Nasar

This study uses advanced telemetry in cynomolgus macaques to monitor physiological parameters after EEEV aerosol challenge, revealing severe alterations in cardiac and neurological functions leading to euthanasia.

bioRxiv · Dec 21, 2020Microbiology

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

J. Luban, R. Sattler, E. Muhlberger, J. D. Graci, L. Cao, M. Weetall, C. Trotta, J. M. Colacino, S. Bavari, C. Strambio-De-Castillia, E. L. Suder, Y. Wang, V. Soloveva, K. Cintron-Lue, N. A. Naryshkin, , S. Peltz

This paper evaluates PTC299's ability to inhibit SARS-CoV-2 replication and reduce inflammatory cytokine production in tissue culture models.

bioRxiv · Aug 5, 2020Immunology