Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis
K. K. Chaudagar, R. Srikrishnan, S. Mei, T. Hirz, Y.-M. Hu, A. Argulian, B. Labadie, K. Desai, S. Grimaldo, D. Kahramangil, R. Nair, S. D Souza, D. Zhou, M. Li, F. Doughan, , A. Patnaik
This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.
bioRxiv · Sep 15, 2023 · PreprintCancer Biology