Author

K. Harvey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 10 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Organism:human· 9 Research Focus:cell type annotation· 6 Research Focus:differential expression· 5 Assay:bulk RNA-seq· 4 Research Focus:gene regulatory network inference· 4 Organism:mouse· 4 Assay:proteomics· 3

Frequent Co-Authors

A. Swarbrick· 8 shared C.-L. Chan· 6 shared G. Al-Eryani· 5 shared S. O'Toole· 5 shared A. S. Cazet· 4 shared D. L. Roden· 4 shared E. Lim· 4 shared N. Bartonicek· 4 shared

Activity by Year

2017-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersCancer Biology

A. Swarbrick

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Author profile →

11 papers

Recent·Most cited

Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer

K. Wahi, N. Freidman, Q. Wang, M. Devadason, L.-E. Quek, A. Pang, L. Lloyd, M. Larance, F. Zanini, K. Harvey, S. O'Toole, Y. F. Guan, J. Holst

The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.

bioRxiv · Feb 21, 2024Cancer Biology

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

T. Wang, K. Harvey, J. Reeves, D. L. Roden, N. Bartonicek, J. Yang, G. Al-Eryani, D. Kaczorowski, C.-L. Chan, J. Powell, S. O'Toole, E. Lim, A. Swarbrick

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

bioRxiv · Apr 6, 2023 · PreprintCancer Biology

snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling

A. F. Vallejo, K. Harvey, T. Wang, K. Wise, L. M. Butler, J. Polo, J. T. Plummer, A. Swarbrick, L. G. Martelotto

This paper introduces snPATHO-Seq, a method for high-quality single nucleus RNA sequencing from FFPE samples, showing improved sensitivity and accuracy compared to existing methods.

bioRxiv · Aug 23, 2022 · PreprintCancer Biology

Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancers

G. Al-Eryani, N. Bartonicek, C.-L. Chan, A. Anderson, K. Harvey, S. Z. Wu, D. Roden, T. Wang, J. Reeves, B. Z. Yeung, E. Masle-Farquhar, C. C. Goodnow, C. Ma, T. G. Phan, J. Lundeberg, , A. Swarbrick

The paper integrates single-cell RNA and protein data from breast cancer samples to identify novel lymphocyte phenotypes and their clinical relevance.

bioRxiv · May 31, 2022 · PreprintImmunology

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer

K. Chaudagar, H. M. Hieromnimon, R. Khurana, B. Labadie, T. Heirz, S. Mei, R. Hasan, J. Shafran, A. Kelley, E. Apostolov, G. Al-Eryani, K. Harvey, S. Rameshbabu, M. Loyd, K. Bynoe, , A. Patnaik

The paper shows that inhibiting lactate production in tumor cells suppresses PTEN/p53-deficient prostate cancer growth by activating macrophage phagocytosis.

bioRxiv · May 12, 2022Cancer Biology

TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complex

N. Merritt, K. Garcia, D. Rajendran, Z.-Y. Lin, X. Zhang, K. Mitchell, N. Borcherding, C. Fullenkamp, M. Chimenti, A.-C. Gingras, K. Harvey, M. R. Tanas

This study identifies the ATAC histone acetyltransferase complex as an oncogenic driver in EHE by showing TAZ-CAMTA1 and YAP-TFE3 recruit it to modulate transcription and chromatin structure.

bioRxiv · Sep 7, 2020Cancer Biology

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

X. Zhang, L. Yang, P. Szeto, Y. Zhang, K. Amarasinghe, J. Li, C. McLean, M. Shackleton, K. Harvey

This study shows that YAP, a Hippo pathway protein, promotes melanoma cell invasion and metastasis, with specific target genes mediating these effects.

Oncogene · Jun 19, 2020Peer-reviewedCancer Biology

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

S. Z. Wu, D. L. Roden, C. Wang, H. Holliday, K. Harvey, A. S. Cazet, K. J. Murphy, B. Pereira, G. Al-Eryani, N. Bartonicek, R. Hou, J. R. Torpy, S. Junankar, C.-L. Chan, E. Lam, , A. Swarbrick

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

bioRxiv · Jun 4, 2020Cancer Biology

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

S. Z. Wu, D. L. Roden, G. Al-Eryani, N. Bartonicek, K. Harvey, A. S. Cazet, C.-L. Chan, S. Junankar, M. N. Hui, E. Millar, J. Beretov, L. Horvath, A. M. Joshua, P. Stricker, J. S. Wilmott, , A. Swarbrick

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.

bioRxiv · Jun 4, 2020Cancer Biology

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1

W. S. Teo, H. Holliday, N. Karthikeyan, A. S. Cazet, D. L. Roden, K. Harvey, C. V. Konrad, R. Murali, B. A. Varghese, A. P. T., C.-L. Chan, A. McFarland, S. Junankar, S. Ye, J. Yang, , R. Nair

This study shows that Id proteins promote a cancer stem cell phenotype in triple negative breast cancer by negatively regulating Robo1, leading to Myc activation.

bioRxiv · Mar 11, 2020 · PreprintCancer Biology

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

A. S. Cazet, M. N. Hui, B. L. Elsworth, S. Z. Wu, D. Roden, C.-L. Chan, J. N. Skhinas, R. Collot, J. Yang, K. Harvey, M. Z. Johan, C. Cooper, R. Nair, D. Herrmann, A. McFarland, , A. Swarbrick

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.

bioRxiv · Nov 8, 2017Cancer Biology