S. Mei

Chloride Homeostasis Regulates cGAS-STING Signaling

This study shows chloride homeostasis regulates cGAS-STING signaling by affecting 23-cGAMP production, STING polymerization, and cytokine production in immune cells.

Androgen blockade primes NLRP3 in macrophages to induce tumor phagocytosis

This study shows that androgen blockade increases NLRP3 in macrophages, which when combined with NLRP3 agonist, enhances cancer cell phagocytosis and tumor control in a mouse model of prostate cancer.

Do inoculated microbial consortia perform better than single strains in living soil? A meta-analysis

This study compares single-species and microbial consortium inoculation effects on biofertilization and bioremediation in soil, finding consortia more effective in field settings.

KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres

KaryoCreate generates chromosome-specific aneuploidy by targeting centromeres with CRISPR, showing it can induce gains or losses of targeted chromosomes in human cells.

A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma

The paper identifies a transcriptional signature in primary ccRCC tumors that predicts metastatic potential and patient survival.

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer

The paper shows that inhibiting lactate production in tumor cells suppresses PTEN/p53-deficient prostate cancer growth by activating macrophage phagocytosis.

Integrated single-cell and spatial transcriptomic analyses unravel the heterogeneity of the prostate tumor microenvironment

This study uses single-cell and spatial transcriptomic analyses to characterize the prostate tumor microenvironment, revealing immune suppression and high angiogenic activity.

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

Skin Delivery of Modified Vaccinia Ankara Viral Vectors Generates Superior T Cell Immunity Against a Respiratory Viral Challenge

This study shows that skin scarification delivery of MVA vectors generates robust T cell immunity against respiratory viral challenges, outperforming other routes and suggesting its potential for vaccines like COVID-19.

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

The paper identifies a subpopulation of malignant Schwann cell precursor-like cells in neuroblastoma that connects adrenergic and mesenchymal tumor cells, suggesting intratumoral plasticity mechanisms.

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment

The paper identifies an immunosuppressive microenvironment in human prostate cancer bone metastases and shows that disrupting the CCL20-CCR6 axis can restore T cell reactivity and improve survival in mice.

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

The paper profiles synovial sarcoma tumors to show that the SS18-SSX fusion drives oncogenic programs, which are repressed by immune cells and can be targeted with HDAC and CDK4/6 inhibitors.

The permeabilized SecY protein-translocation channel can serve as a nonspecific sugar transporter

This paper shows that modifying the SecY protein-translocation channel in bacteria allows it to transport various sugars, enabling rapid growth on multiple monosaccharides and bypassing typical transport limitations.

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

This paper introduces t-CyCIF, a method for highly multiplexed immunofluorescence imaging of FFPE tissues using conventional microscopes, and demonstrates its application in analyzing tumor antigens and immune markers.