Author

A. Kelley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Patnaik· 2 shared A. Solanki· 2 shared B. Labadie· 2 shared C. Drovetsky· 2 shared E. Markiewicz· 2 shared J. Shafran· 2 shared K. Bynoe· 2 shared S. Rameshbabu· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. Patnaik

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis

K. K. Chaudagar, H. Hieromnimon, A. Kelley, B. Labadie, J. Shafran, S. Rameshbabu, C. Drovetsky, K. Bynoe, A. Solanki, E. Markiewicz, X. Fan, M. Loda, A. Patnaik

This study shows that blocking lactate-producing pathways in PTEN/p53-deficient prostate cancer enhances macrophage phagocytosis, leading to durable tumor control in mice.

bioRxiv · May 23, 2023Cancer Biology

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer

K. Chaudagar, H. M. Hieromnimon, R. Khurana, B. Labadie, T. Heirz, S. Mei, R. Hasan, J. Shafran, A. Kelley, E. Apostolov, G. Al-Eryani, K. Harvey, S. Rameshbabu, M. Loyd, K. Bynoe, , A. Patnaik

The paper shows that inhibiting lactate production in tumor cells suppresses PTEN/p53-deficient prostate cancer growth by activating macrophage phagocytosis.

bioRxiv · May 12, 2022Cancer Biology

HIV-1 promoter is gradually silenced when integrated into BACH2

A. Inderbitzin, Y. L. Kok, L. Jörimann, A. Kelley, K. Neumann, D. Heinzer, T. Cathomen, K. J. Metzner

This study shows that HIV-1 promoters integrated into BACH2 are gradually silenced over time in Jurkat T-cells, without affecting BACH2 expression, potentially contributing to HIV-1 persistence.

PeerJ · Nov 24, 2020Peer-reviewedMicrobiology

Coexistence holes characterize the assembly and disassembly of multispecies systems

M. T. Angulo, A. Kelley, L. Montejano, C. Song, S. Saavedra

The paper introduces a hypergraph-based formalism to analyze coexistence in multispecies systems, revealing predictable discontinuities called coexistence holes.

bioRxiv · Oct 16, 2020Ecology

Structural basis of peptidoglycan endopeptidase regulation

J.-H. Shin, A. Sulpizio, A. Kelley, L. Alvarez, S. Murphy, F. Cava, Y. Mao, M. A. Saper, T. Doerr

This study solves the crystal structure of ShyA, a peptidoglycan endopeptidase, revealing a regulatory mechanism involving conformational changes that activate its catalytic activity.

bioRxiv · Nov 17, 2019Microbiology