Methionine Metabolism Controls the B-cell EBV Epigenome and Viral Latency
R. Guo, J. H. Liang, Y. Zhang, M. Lutchenkov, Z. Li, Y. Wang, V. Trujillo-Alonso, R. Puri, L. Giulino-Roth, B. Gewurz
This study shows that methionine metabolism regulates EBV epigenetic states and latency in B-cells, with methionine restriction impairing viral gene silencing and immune evasion.
bioRxiv · Feb 24, 2022Microbiology