Author

B. Gewurz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:chromatin & epigenetic regulation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. Guo· 4 shared B. Zhao· 2 shared Y. Zhang· 2 shared A. Kossenkov· 1 shared C. Jiang· 1 shared C. Wang· 1 shared D. Maestri· 1 shared E. Cesarman· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersMicrobiology

R. Guo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression

Y. Liao, J. Yan, N. R. Beri, L. G. Roth, E. Cesarman, B. Gewurz

This study investigates how GC cytokines regulate EBV latency gene expression and epigenetic remodeling, revealing distinct roles for STAT3 and STAT5 in silencing EBNA and activating LMP1 promoters.

PLOS Pathogens · Apr 29, 2024Peer-reviewedMicrobiology

Methionine Metabolism Controls the B-cell EBV Epigenome and Viral Latency

R. Guo, J. H. Liang, Y. Zhang, M. Lutchenkov, Z. Li, Y. Wang, V. Trujillo-Alonso, R. Puri, L. Giulino-Roth, B. Gewurz

This study shows that methionine metabolism regulates EBV epigenetic states and latency in B-cells, with methionine restriction impairing viral gene silencing and immune evasion.

bioRxiv · Feb 24, 2022Microbiology

The Nuclear Lamina binds the EBV genome during latency and regulates viral gene expression

L. B. Caruso, R. Guo, K. Keith, J. Madzo, D. Maestri, S. Boyle, J. Wasserman, A. Kossenkov, B. Gewurz, I. Tempera

bioRxiv · Aug 5, 2021Microbiology

Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-cell Growth and Survival

J.-H. Liang, C. Wang, S. P. Tung Yiu, B. Zhao, R. Guo, B. Gewurz

This study investigates the role of CTPS1 and CTPS2 in EBV-infected B-cells, showing their importance in cell growth and survival, and suggests they are potential therapeutic targets.

bioRxiv · Jan 8, 2021Cancer Biology

Histone loaders CAF1 and HIRA restrict Epstein-Barr virus B-cell lytic reactivation

Y. Zhang, C. Jiang, S. J. Trudeau, Y. Narita, B. Zhao, M. Teng, R. Guo, B. Gewurz

This study identifies CAF1 and HIRA as host histone chaperones essential for maintaining Epstein-Barr virus latency by restricting lytic reactivation in Burkitt cells.

bioRxiv · Apr 28, 2020Microbiology