R. Guo

Pan-cancer virtual spatial transcriptomics from routine histology with Phoenix

Phoenix predicts spatially resolved single-cell gene expression from histology, identifying new biomarkers and validating them across cancers and treatment regimens.

Microbial single-cell omics in situ

The paper reports a method using LIFT technology to obtain high-quality microbial single-cell genomes or transcriptomes from complex samples and demonstrates its application to study cell-fate commitment in sporulation.

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

A Novel Support Vector Machine-Based One-Day, Single-Dose Prediction Model of Genotoxic Hepatocarcinogenicity in Rats

This paper develops a support vector machine-based model to predict genotoxic hepatocarcinogens in rats using gene expression data from a single dose and day of exposure.

Analytical code sharing practices in biomedical research

This study analyzes code sharing practices in biomedical research and finds that less than half of manuscripts share analytical code, with significant associations between code availability statements and actual code sharing.

Theranostic Bottle-Brush Polymers Tailored for Universal Solid-Tumour Targeting

This study develops bottle-brush polymers optimized for tumour targeting, showing improved delivery efficacy and reduced toxicity in various tumour models.

Lipid Bilayer Strengthens the Cooperative Network of Membrane Proteins

This study shows that lipid bilayers enhance membrane protein stability and their response to external stimuli by influencing hydrophobic thickness and amphiphile packing.

Characterization of Target Gene Regulation by the Two Epstein-Barr Virus Oncogene LMP1 Domains Essential for B-cell Transformation

This study identifies TES1 as critical for LCL survival and characterizes its gene regulatory effects compared to TES2.

Cataloguing and profiling of the gut virome in Chinese populations uncover extensive viral signatures across common diseases

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

Comprehensive investigation and regulatory function of lncRNAs engaged in western honey bee larval immune response to Ascosphaera apis invasion

This study identifies and analyzes lncRNAs in western honey bee larvae infected with Ascosphaera apis, revealing their regulatory roles in immune responses through transcriptome analysis and ceRNA network analysis.

A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

Meta-analysis of fecal metagenomes reveals global viral signatures and its diagnostic potential for colorectal cancer and adenoma

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian

This study investigates microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian using RNA-seq and small RNA-seq data, identifying miRNA-target mRNA interactions and their roles in glycolysis, virulence, and immune response.

CircRNA-regulated immune response of Asian honey bee workers to microsporidian infection

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

Sex differences in the nasal microbiome of healthy young adults

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

Methionine Metabolism Controls the B-cell EBV Epigenome and Viral Latency

This study shows that methionine metabolism regulates EBV epigenetic states and latency in B-cells, with methionine restriction impairing viral gene silencing and immune evasion.

Single-cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction

This study uses single-cell RNA sequencing to analyze cardiac immune cell dynamics after myocardial infarction in mice, identifying key immune subsets and their roles in disease progression.

Local conjugation of auxin by the GH3 amido synthetases is required for normaldevelopment of roots and flowers in Arabidopsis

This study shows that GH3 amido synthetases conjugate auxin, and their deletion causes developmental defects in Arabidopsis roots and flowers.

Lupus Gut Microbiota Transplants Cause Autoimmunity and Inflammation

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

The Nuclear Lamina binds the EBV genome during latency and regulates viral gene expression

Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

Analysis of the mechanism of Aldo-keto reductase dependent cis-platin resistance in HepG2 based on transcriptomic and NADH metabolic analysis

The paper investigates how AKR1C and NADH contribute to cis-platin resistance in HepG2 cells using transcriptomic and metabolic analysis.

Development of a mini-replicon-based reverse-genetics system for rice stripe tenuivirus

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

Co3O4 /PAn Magnetic Nanoparticle-Modified Electrochemical Immunosensor for Azocyclotin

The paper develops an electrochemical immunosensor for detecting azocyclotin residues using Co3O4/PAn nanoparticles, achieving good sensitivity and accuracy in agricultural samples.

Dysbiotic oral and gut viromes in untreated and treated rheumatoid arthritis patients

This study analyzes oral and gut viromes in RA patients and controls to explore their potential role in RA development.

Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-cell Growth and Survival

This study investigates the role of CTPS1 and CTPS2 in EBV-infected B-cells, showing their importance in cell growth and survival, and suggests they are potential therapeutic targets.

Precision-targeted metabolomics method characterizes differential metabolomes in multiple-biological matrixes and cell-mitochondria

This paper introduces a precision-targeted metabolomics method capable of analyzing diverse biological matrices and identifies differential metabolomes in rats with CCl4-induced hepatitis.