Cell BiologybioRxiv
Human pluripotent reprogramming with CRISPR activators
J. Weltner, D. Balboa, S. Katayama…·T. Otonkoski
This study reprograms human skin fibroblasts into iPSC using CRISPRa, showing that targeting an Alu-motif enhances reprogramming efficiency by improving activation of NANOG and REX1.
DOI 10.1038/s41467-018-05067-x