MicrobiologybioRxiv
Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice
M. M. Hernandez, A. Fahrny, A. Jayaprakash…·V. Simon
This study shows that HIV variants with suboptimal anti-APOBEC3G activity are attenuated without treatment but gain a fitness advantage under antiretroviral therapy in humanized mice.
DOI 10.1128/jvi.01543-19