Author

M. M. Pinney

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Biophysics· 1

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:structural biology· 1

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A. S. Powers· 1 shared D. Herschlag· 1 shared F. Yabukarski· 1 shared J. S. Fraser· 1 shared J. T. Biel· 1 shared T. Doukov· 1 shared

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2020-2020 · peak 1/yr

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1 shared paperBiophysics

A. S. Powers

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1 paper

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BiophysicsbioRxivJun 4, 2020

Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles

F. Yabukarski, J. T. Biel, M. M. Pinney…·D. Herschlag

This study uses X-ray crystallography to analyze enzyme active site positioning and motions, finding limited conformational changes and challenging existing catalytic mechanisms.

DOI 10.1073/pnas.2011350117

structural biologyexperimental assay

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