Author

A. S. Powers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:structural biology· 2

Frequent Co-Authors

R. Dror· 2 shared R. O. Dror· 2 shared A. G. Chemparathy· 1 shared A. Inoue· 1 shared A. Makriyannis· 1 shared A. Manglik· 1 shared B. K. Kobilka· 1 shared C. Azumaya· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

R. Dror

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

M. Xu, T. Neelands, A. S. Powers, Y. Liu, S. D. Miller, G. Pintilie, J. Du Bois, R. O. Dror, W. Chiu, M. Maduke

The paper reports cryoEM structures of human CLC-2 chloride channels, revealing a ball-and-chain gating mechanism involving an N-terminal hairpin peptide.

bioRxiv · Aug 13, 2023Biophysics

Modulation of cannabinoid receptor signaling by endocannabinoids

K. Krishna Kumar, M. J. Robertson, E. Thadhani, H. Wang, C.-M. Suomivuori, A. S. Powers, L. Ji, S. P. Nikas, M. Gerasi, K. Vemuri, R. Dror, A. Inoue, A. Makriyannis, G. Skiniotis, B. K. Kobilka

This study investigates how endocannabinoids modulate CB1 receptor signaling by comparing their activation of Gi1 with synthetic cannabinoids and revealing structural differences in ligand binding.

bioRxiv · Aug 6, 2022 · PreprintBiochemistry

Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles

F. Yabukarski, J. T. Biel, M. M. Pinney, T. Doukov, A. S. Powers, J. S. Fraser, D. Herschlag

This study uses X-ray crystallography to analyze enzyme active site positioning and motions, finding limited conformational changes and challenging existing catalytic mechanisms.

bioRxiv · Jun 4, 2020Biophysics

Leveraging non-structural data to predict structures of protein-ligand complexes

J. M. Paggi, J. A. Belk, S. A. Hollingsworth, N. Villanueva, A. S. Powers, M. J. Clark, A. G. Chemparathy, J. E. Tynan, T. K. Lau, R. K. Sunahara, R. O. Dror

This paper presents a statistical framework combining physics-based and ligand-based methods to predict protein-ligand complex structures, improving pose prediction accuracy for drug targets.

bioRxiv · Jun 1, 2020 · PreprintBiophysics

Structure of human ferroportin bound to hepcidin reveals mechanisms of iron homeostasis

C. Billesboelle, C. Azumaya, R. C. Kretsch, A. S. Powers, S. Gonen, S. Schneider, T. Arvedson, R. Dror, Y. Cheng, A. Manglik

This study determines the cryo-EM structures of human ferroportin bound to hepcidin and identifies mechanisms of iron homeostasis regulation.

bioRxiv · Mar 16, 2020 · PreprintBiochemistry