BioengineeringbioRxiv
In Vitro Platform Establishes Antigen-Specific CD8+ T Cell Cytotoxicity to Encapsulated Cells via Indirect Antigen Recognition
Y. Li, A. W. Frei, E. Yang…·C. L. Stabler
This paper establishes an in vitro platform to study CD8+ T cell cytotoxicity against encapsulated cells via indirect antigen recognition, revealing that hydrogel encapsulation blocks direct T cell activation but allows indirect activation through host APCs.
DOI 10.1016/j.biomaterials.2020.120182