A. L. Bayer

A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated Myocarditis

This study identifies CXCR3-CXCL9/10 axis as a therapeutic target for ICI-mediated myocarditis using mouse models and human patient data.

AKT2 Loss Impairs BRAF-Mutant Melanoma Metastasis

This study shows AKT2 promotes melanoma metastasis while AKT1 is critical for tumor initiation, suggesting AKT2 as a therapeutic target in BRAF-mutant melanoma.

Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T cells

This study shows that IGF1 and IL-2 together expand regulatory T cells more effectively than either alone, through distinct signaling pathways and receptor expression changes.

AKT1 is Required for a Complete Palbociclib-induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma

This study shows AKT1 is required for Palbociclib-induced senescence in BRAF-V600E melanoma cells, acting through NF-kB but not cGAS-STING.

In Vitro Platform Establishes Antigen-Specific CD8+ T Cell Cytotoxicity to Encapsulated Cells via Indirect Antigen Recognition

This paper establishes an in vitro platform to study CD8+ T cell cytotoxicity against encapsulated cells via indirect antigen recognition, revealing that hydrogel encapsulation blocks direct T cell activation but allows indirect activation through host APCs.