M. Mangler

Inhibition of ADAM17 increases cytotoxic effect of cisplatin in cervical spheroids and organoids

This study shows that inhibiting ADAM17 enhances cisplatin's cytotoxic effect in cervical cancer spheroids and organoids, suggesting ADAM17 as a potential target for overcoming chemoresistance.

γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

This study evaluates γδ T cell-mediated cytotoxicity against cervical organoids, finding that HPV-transformed and cancerous organoids are more susceptible than healthy ones.

Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids

This study shows that Chlamydia coinfection with HPV disrupts cellular and genomic integrity safeguards in ectocervical organoids, promoting neoplastic progression.

Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment

This study shows that HGSOC organoids require a low Wnt environment for growth, similar to genetically altered FT organoids, indicating early niche changes support tumor outgrowth.

Transition of Wnt signaling microenvironment delineates the squamo-columnar junction and emergence of squamous metaplasia of the cervix

The paper identifies that Wnt signaling dynamics in the stroma regulate the squamo-columnar junction and the emergence of squamous metaplasia in the cervix, without a localized stem cell population at the boundary.