H. Berger

Helicobacter pylori cancer associated CagA protein drives intestinal metaplastic transition in human gastric organoids

This study shows that Helicobacter pylori's CagA protein induces intestinal metaplasia in human gastric organoids by activating STAT3 and increasing intestinal markers.

γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

This study evaluates γδ T cell-mediated cytotoxicity against cervical organoids, finding that HPV-transformed and cancerous organoids are more susceptible than healthy ones.

Polaramycin B, and not physical interaction, is the signal that rewires fungal metabolism in the Streptomyces - Aspergillus interaction.

The paper identifies polaramycin B as the signaling molecule, not physical contact, that triggers metabolic rewiring in the Streptomyces-Aspergillus interaction by inducing ORS production and altering gene expression.

Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids

This study shows that Chlamydia coinfection with HPV disrupts cellular and genomic integrity safeguards in ectocervical organoids, promoting neoplastic progression.

Activation of silent secondary metabolite gene clusters by nucleosome map-guided positioning of the synthetic transcription factor VPR-dCas9

This paper introduces a synthetic transcription factor system to activate silent secondary metabolite gene clusters in Aspergillus nidulans by positioning VPR-dCas9 using nucleosome maps.

Colibactin DNA damage signature indicates causative role in colorectal cancer

The paper identifies a mutational signature caused by colibactin in human colorectal cancers.

Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment

This study shows that HGSOC organoids require a low Wnt environment for growth, similar to genetically altered FT organoids, indicating early niche changes support tumor outgrowth.

Transition of Wnt signaling microenvironment delineates the squamo-columnar junction and emergence of squamous metaplasia of the cervix

The paper identifies that Wnt signaling dynamics in the stroma regulate the squamo-columnar junction and the emergence of squamous metaplasia in the cervix, without a localized stem cell population at the boundary.